關(guān)鍵字：JSN,日本,慢性腎病,慢性腎臟病,CKD,實(shí)踐指南

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簡(jiǎn)介：A decreased GFR (50 ml/min/1.73 m2 or lower for patients aged 40 to 69 years and 40 ml/min/1.73 m2 or lower for patients aged 70 years and over), proteinuria and albuminuria are risk factors for ESKD. CKD was defined for the first time in one of the clinical guidelines of the K/DOQI published in 2002 by NKF. CKD stages 3–5 have been known as risk factors for ESKD. In the Japanese population, eGFR B50 ml/min/m2 in patients aged 40–69 years and 40 ml/min/1.73 m2 in patients aged 70 years and over are risk factors for ESKD. Proteinuria and albuminuria are also proportionally related to the risk for ESKD. A meta-analysis of 11 observational studies of non-diabetic nephropathy indicated that proteinuria before treatment was a strong prognostic factor for the doubling of serum creatinine and ESKD. This finding could be extrapolated to a normal population and pretreated CKD patients and those on current treatment. Decreased proteinuria and albuminuria by RAS inhibitors are implicated in the suppression of progression of CKD.