This is a review of the 5 th edition Renal Association guidelines chapter on CKD-MBD. The current guideline was published in the period following release of the KDIGO guidelines which prompted changes in guidelines around the world. For this updated version, a systematic literature review was performed using www.pubmed.gov, focusing on the topics of:

Mineral bone disorder

Renal osteodystrophy

Hyperphosphat(a)emia

Calcium

PTH

Vascular calcification

Phosphate binder

The search covered the period from Dec 2009 to October 2013. Articles not written in English were not assessed. Articles available in abstract forms; letters; case reports; editorials or review articles were also excluded. Articles were assessed for relevance to the guideline topic, eligibility for inclusion in the evidence base for that guideline and methodological quality. Articles were considered of particular relevance if they were describing:

? ?Meta-analysis of several trials

? ?Cochrane systematic reviews

? ?Prospective randomized trials

? ?NICE clinical guidelines